HGH is released by the pituitary gland in a series of pulses. One series just after falling asleep, and another about 2 hours after getting up in the morning. The amount of HgH in the blood is very small, and varies rapidly over time. This renders it unsuitable as a monitor of growth hormone activity. IGF-1 is much more abundant, is produced in direct response to HgH human growth hormone, and has a consistent diurnal pattern.
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